🎉 Our latest multidisciplinary work, “AI Identifies Compounds that Protect Retinal Ganglion Cells and Optic Nerve in Neurodegeneration by Alleviating ER Stress,” is currently under review at Nature Communications. In this study, we developed an AI-driven pipeline utilizing ImageMol, a visually pre-trained molecular representation model, to discover neuroprotective agents targeting ER stress for glaucoma. By virtually screening over 10,000 clinically tested compounds, we successfully identified and experimentally validated two candidates (leonurine hydrochloride and chlorogenic acid) that preserve retinal ganglion cell (RGC) viability and improve visual function in vivo. This provides a scalable, mechanism-specific framework for drug discovery in neurodegenerative diseases.